產(chǎn)品詳情介紹
肝細(xì)胞生長(zhǎng)因子(hepatocyte growth factor，HGF)是存在于急性肝損傷動(dòng)物血漿中的蛋白因子，它能刺激肝細(xì)胞的DNA合成，且在肝再生過(guò)程中起重要作用。HGF由728個(gè)氨基酸構(gòu)成，其活性形式是由一條重鏈(α鏈)和一條輕鏈(β鏈)組成的異二聚體，α鏈N-端有一發(fā)夾結(jié)構(gòu)；β鏈有絲氨酸蛋白酶樣結(jié)構(gòu)[1-3]。HGF刺激有絲分裂、細(xì)胞運(yùn)動(dòng)和基質(zhì)侵襲的能力使其在血管生成、腫瘤發(fā)生、組織再生和心肌保護(hù)中發(fā)揮核心作用[4-5]。HGF還與多種癌癥有關(guān)，包括肺癌、胰腺癌、甲狀腺癌、結(jié)腸癌和乳腺癌[6]。
[1] Thaler FJ, Michalopoulos GK. Hepatopoietin A: partial characterization and trypsin activation of a hepatocyte growth factor. Cancer Res. 1985, 45(6):2545-9.
[2] Selden C, Johnstone R, Darby H, Gupta S, Hodgson HJ. Human serum does contain a high molecular weight hepatocyte growth factor: studies pre- and post-hepatic resection. Biochem Biophys Res Commun. 1986, 139(1):361-6.
[3] Zarnegar R, Michalopoulos G. Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res. 1989, 49(12):3314-20.
[4] ?ztürk D, Koca AO, Keskin M, ?ztürk B, O?uz EF, Turhan T, Bulu? H. Patients who received sleeve gastrectomy have lower plasma osteopontin levels than those who did not. Clinics (Sao Paulo). 2024, 79:100352.
[5] Sommer P, Schreinlechner M, et al. Hepatocyte growth factor as indicator for subclinical atherosclerosis. Vasa. 2024, 53(2):120-128.
[6] Okano Y, Kase Y, Suematsu Y, Nakamura M, Okano H. Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue. Inflamm Regen. 2024, 44(1):10.
