產(chǎn)品詳情介紹
白介素-1 alpha (Interleukin-1 alpha,IL-1a)是一種在多種細(xì)胞中廣泛表達(dá)的組成型蛋白,屬于IL-1家族。它是一種關(guān)鍵的前炎癥細(xì)胞因子,參與了多種生理和病理過程,包括免疫反應(yīng)、炎癥反應(yīng)和組織損傷后的修復(fù)[1]。IL-1α在健康狀態(tài)下幾乎存在于所有細(xì)胞類型中,但在壞死細(xì)胞死亡時作為生物活性介質(zhì)被釋放出來。IL-1α與IL-1β共享同一受體,通過與IL-1受體1(IL-1R1)結(jié)合,誘導(dǎo)產(chǎn)生炎癥反應(yīng)[2-3]。
[1] Rider P, Carmi Y, Voronov E, et al. Interleukin-1α. Seminars in immunology. Academic Press, 2013, 25(6): 430-438.
[2] Malik A, Kanneganti T D. Function and regulation of IL‐1α in inflammatory diseases and cancer. Immunological reviews, 2018, 281(1): 124-137.
[3] Gelfo V, Romaniello D, et al. Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies. Int J Mol Sci, 2020 Aug 20;21(17):6009.